More about microtubules?
Microtubules are critical components of the cytoskeleton and play several major roles in cells. Tubulin is a well-know target in oncology as they are of particular importance during mitosis, when they form a mitotic spindle, a bipolar array of microtubules and microtubule-binding proteins with chromosomes in the middle. Microtubules are composed of tubulin, a heterodimer of α and β subunits with an apparent molecular mass of 110 kDa. In the presence of GTP, the α and β tubulin heterodimers can polymerize (in-vivo and in-vitro) to form microtubules. Microtubules have a crucial role in facilitating long-distance transport of both proteins and organelles. In neurons, impaired fast axonal transport (FAT) is a hallmarks of tautopathies. Microtubules stabilization reversed FAT (Zhang B, et al.).